Disruption of Gap Junctional Communication within the Ovarian Follicle Induces Oocyte Maturation
نویسندگان
چکیده
منابع مشابه
Gap-junctional communication in mouse cumulus-oocyte complexes: implications for the mechanism of meiotic maturation.
The mechanisms underlying the hormonal stimulation of meiotic maturation are not understood. The most prevalent hypothesis is that hormone-induced maturation is stimulated by an increase in the intracellular messengers, cAMP or Ca2+. This study investigated whether Ca2+ transients in somatic cells can lead to Ca2+ transients in the oocyte, and whether hormones that stimulate meiotic maturation ...
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We have previously reported that androstenedione induces abnormalities of follicle development and oocyte maturation in the mouse ovary. In granulosa cells of the ovarian follicle, androstenedione is aromatized to 17β-estradiol (E2). To determine whether the androgen or estrogen acts directly on the follicle to induce the above-mentioned abnormalities, we compared the effects of a non-aromatiza...
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An endocrine-disrupting chemical, diethylstilbestrol (DES), a nonsteroidal estrogen, triggers oocyte maturation in fish. The morphology (the time course of the change in germinal vesicle breakdown) and an intracellular molecular event (the de novo synthesis of cyclin B) induced by DES were indistinguishable from those induced by a natural maturation-inducing hormone, 17alpha,20beta-dihydroxy-4-...
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Prevalence of Polycystic Ovarian Syndrome(PCOS) in Iran is more than 6%. Therefore we encounter with many PCOS patients. In Vitro Maturation (IVM) of oocytes as an attractive method in ART is considered. Studies show that changes in culture conditions should be administered to make IVM protocol more successful .For this purpose in this study we have set up the beneficial cultures for IVM proced...
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BACKGROUND Previous studies have demonstrated development of antral follicles in cryopreserved human ovarian tissue after autografting and xenografting, thus indicating successful preservation of follicular function. The study aim was to assess whether these follicles could also undergo periovulatory changes in response to hCG. METHODS Ovarian tissue from three patients were dehydrated in pro...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2006
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2005-1011